• #3. Brain Fog not ‘just in your mind’: new insights into physical markers of Cognitive Impairment with Dr William Hu

  • Oct 23 2024
  • Length: 50 mins
  • Podcast
  • 5.0 out of 5 stars (1 rating)

#3. Brain Fog not ‘just in your mind’: new insights into physical markers of Cognitive Impairment with Dr William Hu

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  • Summary

  • Director for the Center for Healthy Aging Research at the Rutgers Institute for Health, Dr William Hu is a cognitive neurologist: he studies and treats patients whose thinking is affected by disease.

    Typically Dr Hu was dealing with Alzheimer's and related dementias in patients who were cognitively ageing whilst otherwise healthy, and those whose cognition was affected by their illness such as HIV or MS. But since the Covid pandemic began, Dr Hu started seeing large numbers of patients whose ‘brain fog’ was sufficiently severe that they suspected they had early onset Alzheimer's, along with those who knew that their cognition, memory and thinking had demised to a degree that they were aware of it, but standard testing was inconclusive.

    In this week’s episode we discuss the way in which Hu and his team at Rutgers used brain imaging and analysis of cerebrospinal fluid (CSF), which enabled them to identify changes in the brain of patients with brain fog. Their study, published in Cell, revealed that they could see that these patients had the markers of persistently activated immune function in the brain. Whilst they were unable to detect SARS CoV-2 virus in the CSF, their findings correlate with the theory that those with Long Covid have viral persistence, and they were also able to see that this brain activation was no longer present in those that recovered.

    We talk through the implications of these findings for treatment and research into other chronic conditions, and discuss methods that might assist the immune system in recovering from these cognitive impairments and alleviate symptoms. And reassuringly, Hu’s ideas involve trials in treatments that already have FDA approval for other conditions, meaning perhaps resolution is not so far out of reach.

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Profile Image for M

Very informative for people like me with long covid

I really liked the focus on Long Covid and cardiology this week.
Prior to being diagnosed with Long Covid I had a ward management and clinical role within the NHS, I worked full time and beyond.
However, after getting Covid in November 2022 I have had major health issues, including influenza, pneumonia and continual viral respiratory infections meaning I was off sick for over 5 months. Having long Covid has meant that I have had to reduce not only the responsibility involved in my former role but also my contracted hours to the present heavily part time staff nurse job I do now.
However, this doesn't seem to of helped much as I have just returned to work after another 4 months sick leave.

I feel like I have tried everything recommended to me, from improving my activity levels to taking probiotics and anything else anyone suggests might help.

I have been left with severe shortness of breath and atrial flutter (sounds pretty but it it's not at all) which cardiology have tried to address with medications, but this has failed. So I am going to shortly have cardioaversion treatment to see if that might reduce my heart rate.

Day to day the Long Covid and resulting shortness of breath, POTS, PEMS symptoms impact my life greatly, and that's without touching on the brain fog and ME fatigue type symptoms.

I have been using the Visible app and health monitor for around 6 weeks and find it so reassuring to see the evidence of why I feel wiped out after doing just a little on some days, and others being unable even to do anything at all and even the idea of having a shower is just too much. I am so glad that you have created this app and podcast. I will be listening avidly to any suggestions of what I can do to improve my quality of life and rid myself of the curse of Long Covid. Thank you Emily and all the team behind Visible 🙏

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