In today’s episode, Evgeny Lebedev talks about the remarkable potential of ketamine with Dr John Krystal, Professor of neuroscience at the Yale School of Medicine.

Their discussion delves into the world of neurology, what ketamine actually does to our brain and the importance of glutamate receptors in treating depression. Ketamine may have gotten bad press after Friends actor Matthew Perry died of an overdose while receiving treatment with the drug, but for Dr Krystal, it is a critically overlooked solution to the epidemic of mental illness.

Also in this episode:

• Ketamine’s complicated history starting in the 1950s
• The real reason depression leads to suicide
• Why ketamine is effective at dealing with trauma
• The detailed procedure of ketamine therapy
• The importance of ketamine’s “narrow window” dosage
• Ketamine’s reputation and why it needs to change

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In today’s episode, we are excited to be joined by Peter Attia: a longevity expert, physician, and bestselling author.

Peter’s podcast, The Drive, is one of the most popular in the world. Through it, he’s brought cutting edge science to the masses, sharing tips and tricks, some of which are still experimental, on how to boost your chances of ageing well.

Tune into Peter and Evgeny’s conversation on what the former calls “Medicine 3.0” — his blueprint for good health — and how happiness is essential to longevity, not just a bonus. “It doesn’t matter how healthy you are,” Peter says, “if the most important relationships in your life are not happy.”

Topics covered include:

• The difference between health span and lifespan
• How AI can revolutionise clinical trials and the development of new medicines
• ⁠How to regulate glucose levels
• Tips to reducing caloric intake
• Why cancer immunity is under-researched
• How to prevent heart disease
• ⁠Debunking the biggest myths around nutrition

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Evgeny Lebedev joins Dr. Aubrey de Grey, a visionary in biomedical gerontology and co-founder of the SENS Research Foundation.

Known for his radical approach to ageing, Dr. de Grey discusses why some need to awaken from a "pro-ageing trance".

What’s Aubrey’s biological age?

In this episode:

• Why we don’t “have” to age
• Reversing cellular aging
• The ethical questions surrounding life extension
• The societal shifts we might expect if ageing becomes a treatable condition
• The science behind extending the human healthspan

Plus more.

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