Happy New Year! I’m joined today with a very special guest and current primary exam examiner Dr Anthony. In this episode we take a in depth look at the Pharmacokinetics of Propofol TCI. Anthony has curated this talk over multiple years and starts of by explaining the main equations you should know (05:35). We then integrate these equations into the classic Propofol Cp vs Time graph (11:52). This leads us on to talking about the compartment model (20:11) and how this applies to the ‘Marsh’ TCI model (23:25). To help understand the concepts of rate constants (k) Anthony uses his bucket analogy (27:27). Then we apply this knowledge to understand effect site targeting (Ce) and run through some examples of differences in age (41:30) and weight (66:05). Finally, we finish with a brief look at the ‘Eleveld’ Model and the concept of Keo (72:40). A huge thank you to Anthony and as always if you have any feedback let me know.

Sources/Credit:

All equations/graphs/diagrams/tables – Miller’s Anesthesia 10th Edition 2025

All TCI calculations – simtiva.app

End Episode Song – “The Volatiles”

I’m joined today by a special guest Justin and we go through an overlooked topic of ‘Immunology & Hypersensitivity.’ The first learning objective is to review how the body defends against infection (05:46) and then look how this is effects under anaesthesia (14:06). Finally, we have a long conversation about the pathophysiology of hypersensitivity (16:22) and the clinical context of the treatment of anaphylaxis (24:18). I want to thank Justin again for joining me today and as always if you have any feedback let me know.

Today is the last topic of our cardiac physiology series “Measurement.” I start of by looking at different techniques to measure non-invasive BP from auscultation (01:31) to oscillometry (07:03). Then I look at an invasive method being arterial lines and this is divided into how it works (11:15) and sources of error (17:54). The last LO for today covers different techniques to measure cardiac output (27:41). To finish as always, we look at the past SAQs (33:35). Thanks for listening! As always if you have any feedback let me know