In this episode, we're tackling a question I’ve been hearing a lot: What happens if you want to stop your GLP-1 medication (like Ozempic, Wegovy, Mounjaro, Zepbound, or Saxenda)? Whether you’re making this decision voluntarily or because circumstances force it, I’ll walk you through evidence-based strategies to minimize weight regain and ensure the best outcomes.

Here’s what I’ll cover today:

1. What happens when you stop GLP-1 medications?
   
   
2. • GLP-1s are not just weight loss tools; they treat a chronic disease—obesity.
   • Weight regain after stopping is common and tied to metabolic and hormonal adaptations.

1. What research tells us about this transition:
   
   
2. • The STEP-1 Extension Trial showed patients regained about two-thirds of the weight they lost after stopping semaglutide, even with lifestyle interventions.
   • A Diabetes, Obesity and Metabolism study highlights that weight regain is a natural metabolic response, not a failure of willpower.

1. Why long-term GLP-1 use is often recommended:
   
   
2. • Think of GLP-1s like treatment for other chronic diseases, such as diabetes or hypertension. For most people, ongoing therapy is necessary for sustained benefits.

1. Evidence-based strategies for transitioning off GLP-1s:
   
   
2. • Gradual tapering: Slowly reduce your dose under medical supervision.
   • Focus on nutrition: Increase protein intake and monitor your eating habits closely.
   • Prioritize physical activity: Incorporate resistance training to preserve muscle and support your metabolism.
   • Use psychological tools: Employ CBT or other techniques to handle emotional eating and cravings.
   • Consider adjunct therapies: Discuss options like metformin with your doctor.

1. Key takeaway:
   Transitioning off GLP-1s is not one-size-fits-all. It requires close collaboration with your healthcare provider, a strong emphasis on lifestyle habits, and ongoing psychological support. Whatever path you choose, remember this journey is about long-term health, not just weight loss.
   
   

🎧 If you’re looking for guidance on building resilience and consistency to create your healthiest lifestyle, whether you’re on or off GLP-1 medications, check out my coaching program, Best Weight, on my website: www.sashahighmd.com/bestweight.

References from today’s episode:

• STEP-1 Extension Trial: Read more
• SURMOUNT-4: Read more

Copenhagen study on tapering off GLP-1s: Learn more

Welcome to another episode of High on Life! Today, we’re tackling a common challenge for people on GLP-1 medications like Ozempic or Wegovy: the return of hunger. If you’ve been enjoying reduced appetite and suddenly find hunger creeping back in, you’re not alone. It can feel frustrating, but here’s the good news—it’s not an emergency. In this episode, we’ll explore practical strategies to manage hunger in a calm, mindful way.

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In this episode of High on Life, Dr. Sasha High welcomes registered dietitian Tedi Nikova to uncover common nutrition mistakes that sabotage weight loss goals. Tedi, the head coach of the Best Weight program and a dietitian at the High Metabolic Clinic, shares actionable strategies for overcoming these challenges and building sustainable habits.

Key topics include recognizing hidden sugars in drinks and foods, such as sauces, yogurts, and smoothies, and gradually reducing hidden sugars to improve metabolic health. Tedi explains the importance of balancing food tracking with intuitive eating and reconnecting with hunger and fullness cues for a healthier relationship with food. They also discuss the impact of alcohol on metabolism, sleep, and weight management, offering tips for reducing intake while enjoying social settings. Lastly, they explore how rigid diets often fail and highlight the value of tailoring nutrition plans to fit individual lifestyles for long-term success.

If you’re reading to join Best Weight to uncover blind spots and build intentional, sustainable health habits, check us out here: www.sashahighmd.com/bestweight

For additional resources, check out Virta Health: Names for Sugar https://www.virtahealth.com/blog/names-for-sugar