Episodes

  • Glycolysis: Allosteric Regulation of PFK-1

    Glycolysis: Allosteric Regulation of PFK-1
    Jan 15 2025
    This podcast covers the allosteric regulation of Phosphofructokinase 1( PFK-1). A key allosteric activator is F2,6 bis-phosphate, which is produced by PFK-2 in the well-fed state. The production of this molecule is increased by the dephosphorylation of PFK-2, the enzyme responsible for its production. insulin will activate this enzyme by promoting g its dephodphorylation.Thus resulting in higher levels of F2, 6 bis-phosphate in the cytoplasm and resulting in the activation of PFK-1 and Glycolysis.
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    11 mins
  • Cholesterol Summary: Uses & Regulation of Biosynthesis

    Cholesterol Summary: Uses & Regulation of Biosynthesis
    Jan 11 2025
    This podcast covers the cellular uses of cholesterol and a brief summary of its biosyntthesis and its regulation by intracellular levels of cholesterol. Check out the podcast on regulation of HMG CoA reductase below: https://youtu.be/FNSr3G6OTBs?si=da3V5SkXGkM8STsZ Also check out how statins reduce plasma cholesterol below: https://youtu.be/HrwI02Ww3Ew Also check out the he complete podcast on Regulation of Cholesterol Biosynthesis below: https://youtu.be/K1i3P3KPN3g
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    3 mins
  • Classification of Amino Acids

    Classification of Amino Acids
    Jan 3 2025
    Amino acids can be classified as essential or non- essential. They can also be classified by the carbon skeletons they produce during catabolism. These carbon skeletons can be either glucogenic or ketogenic.
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    4 mins
  • A Summary of Metabolism & Its Regulation

    A Summary of Metabolism & Its Regulation
    Dec 28 2024
    A Summary of Metabolism & Its Regulation :This podcast summarizes metabolism and its regulation by hormones. It includes: 1. Definition of metabolism, catabolism, anabolism, and their cellular compartments; 2. The 3 stages of catabolism; 3. The major cellular uses of glucose, amino acids, fatty acids, and cholesterol; 4. The major metabolic pathways that produce energy from dietary carbohydrates and fat; 5. Comparison of the energy (ATP) output from catabolism of glucose , fatty acids, and acetoacetate (ketone bodies); 6. Hormonal regulation of the major metabolic pathways by insulin, glucagon, and epinephrine
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    24 mins
  • Misconceptions About Catabolism of Glucose,Fat, & Amino Acids

    Misconceptions About Catabolism of Glucose,Fat, & Amino Acids
    Dec 20 2024
    This podcast covers some misconceptions about catabolism of glucose , fat (Triacylglycerol) and amino acids. it also compares the energy output from these three dietary components.
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    13 mins
  • Integration of Metabolism: A Summary of Tissue Metabolism

    Integration of Metabolism: A Summary of Tissue Metabolism
    Dec 2 2024
    This podcast covers the major tissue effects of insulin and glucagon in the well-fed state and the fasting state, respectively. The key effects of these hormones on carbohydrate, fat, and protein metabolism in various tissues are summarized.
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    5 mins
  • Cell-Cell Communication

    Cell-Cell Communication
    Nov 17 2024
    Cell-Cell Communication is a fundamental process that is essential for the regulation of metabolism in various organs. Through hormones of the endocrine system, signals are chemically transmitted through the bloostream between different organs. The outcome of a hormone binding its specific receptor in target tissues can produce profound effects on metabolism. Insulin and its effects on the liver, is used as an example of the outcome of communication between the pancreas and the liver.
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    5 mins
  • Catabolism of Alanine, Glutamate & Aspartate

    Catabolism of Alanine, Glutamate & Aspartate
    Oct 29 2024
    This podcast covers the catabolism of alanine, glutamate and aspartate, including the roles of 3 important enzymes alanine transaminase (ALT), aspartate transaminase (AST) and glutamate dehydrogenage in this process. Input of nitrogen into the Urea cycle is provided directly or indirectly through the metabolism of the 3 discussed amino acids.
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    6 mins