Autoimmunity and autoimmune diseases are on the rise. In this episode I look at why this is the case, the mechanisms behind autoimmunity and what we can do to prevent and manage it.

Innate vs adaptive immunity (including B and T cells): https://www.ncbi.nlm.nih.gov/books/NBK279396/#

Molecular mimicry in autoimmunity: https://www.sciencedirect.com/science/article/pii/S0896841118305365#

Autoantibodies: https://pathology.jhu.edu/autoimmune/definitions

The rise of autoimmunity and autoimmune diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918670/#

Intestinal permeability and autoimmunity: https://academic.oup.com/biohorizons/article/doi/10.1093/biohorizons/hzx015/4670557#

'Leaky gut’ syndrome: https://www.medicalnewstoday.com/articles/326117

Autoimmune protocol diet: https://www.healthline.com/nutrition/aip-diet-autoimmune-protocol-diet#how-it-works

Proteus and rheumatoid arthritis; https://www.iomcworld.org/open-access/worldwide-links-between-emproteus-mirabilisem-and-rheumatoid-arthritis-46162.html

Sleep and autoimmunity: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(22)00311-3/fulltext

Stress and autoimmunity: https://www.autoimmuneinstitute.org/articles/stress-autoimmune-disease-navigating-the-complex-relationship/

An expert opinion on the rise in autoimmunity: https://medicine.yale.edu/news-article/why-are-autoimmune-and-allergic-diseases-rising-andrew-wang/

Vitamin D and autoimmunity: https://www.newscientist.com/article/2306132-vitamin-d-supplements-really-do-reduce-risk-of-autoimmune-disease/#ixzz7KF2W0SEL

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Our biomechanics affect us all the time, each and every day and is often ignored when it comes to its impact on health. From hip pain to heartburn, our anatomy and the way we move can have impacts on our health on a daily basis.

Leg length discrepancy: https://www.thebiomechanicsmethod.com/2021/06/01/how-a-leg-length-discrepancy-affects-the-body/

Podiatry and foot biomechanics: https://www.ukpodiatry.com/our-assessments/biomechanical-analysis

Kyphosis exercises: https://www.healthline.com/health/exercise-fitness/kyphosis-exercises#exercises-to-try

World Athletics: https://worldathletics.org/news/press-release/2017-world-championships-athletics-biomechani

The kinetic chain: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174497/

Exercise for constipation: https://www.healthline.com/health/chronic-constipation/exercises-to-relieve-constipation#1

Looking at your phone: https://www.cprtherapy.org/blog/Postural-Awareness-with-Mobile-Devices~6435.html

Douglas Heel (activation therapy): https://douglasheel.com/

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In my book The Health Fix I talk about how I ask patients about their typical day and why that is a great question to ask in order to generate a 'Lifestyle Prescription’.

Looking at your typical day may not be something you’ve done recently or in any detail but it can give you clues to why you may be contributing to some of your symptoms or how you feel.

Carpal tunnel syndrome and sleep position: https://www.athletico.com/2017/04/14/sleep-positioning-carpal-tunnel-syndrome/

Sleep and circadian rhythm tips: https://www.stylist.co.uk/health/sleep/cant-sleep-mistakes/496595

Health trackers and anxiety: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357265/

Caffeine and our genes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242593/

Systems medicine and biology: https://laskerfoundation.org/leroy-hood-there-is-going-to-be-a-fantastic-revolution-in-medicine/

Eating late and sleep disruption: https://health.clevelandclinic.org/is-eating-before-bed-bad-for-you

Microwave ovens and health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242593/

Repressed emotions and dealing with them: https://www.healthline.com/health/repressed-emotions

My IDEAL framework in print: https://www.glamourmagazine.co.uk/article/the-health-fix-dr-ayan-panja-new-years-resolutions

My IDEAL framework on this podcast: https://podcasts.apple.com/gb/podcast/saving-lives-in-slow-motion/id1573742958?i=1000567557435

Our monkey brain: https://podcasts.apple.com/gb/podcast/saving-lives-in-slow-motion/id1573742958?i=1000597803315

THE HEALTH FIX: The Health Fix: Transform your Health in 8 Weeks amazon.co.uk

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Big Pharma gets a lot of bad press, yet most of us have needed to take medication for something at some point in our lives.

How do we minimise the risk of our coming to harm from drugs and what can industry do to work more openly with us?

Diuretic drugs: https://link.springer.com/chapter/10.1007/978-3-642-79565-7_4

Ben Goldacre - a review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635613/

Evidence Based Medicine: https://guides.mclibrary.duke.edu/ebm

Lorcainide story: https://www.bmj.com/content/350/bmj.g7717/rr-1

Anti-arrhythmic drugs: https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/drug-cabinet/anti-arrhythmics

Drug reps and doctors: https://www.npr.org/2024/04/19/1245972805/pharma-reps-have-visited-doctors-for-decades-what-impact-does-it-have-on-patient

The opioid crisis and Oxycontin latest: https://www.bbc.co.uk/news/world-us-canada-60610707

PHQ-9 for depression: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416649/#

Monoclonal antibodies: http://news.bbc.co.uk/1/hi/health/114311.stm

ALLTRIALS: alltrials.net

The NHS and big pharma: https://www.theguardian.com/business/2023/jul/08/its-naive-to-think-this-is-in-the-best-interests-of-the-nhs-how-big-pharmas-millions-are-influencing-healthcare

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The evidence is compelling. Clutter can be harmful to our health in many ways from poor sleep, stress, anxiety and even physical pain. Why is this the case and what can we do about it?

Graham Hill - less stuff, more happiness: https://www.ted.com/talks/graham_hill_less_stuff_more_happiness?subtitle=en

Marie Kondo and her work: https://konmari.com/

Attention and the visual cortex: https://pubmed.ncbi.nlm.nih.gov/21228167/

Fals risk:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10735369/\\

Eating behaviours and hoarding: https://pubmed.ncbi.nlm.nih.gov/25440599/

Procrastination and clutter: https://pubmed.ncbi.nlm.nih.gov/36767429/

Decluttering challenge: https://www.apartmenttherapy.com/10-10-100-decluttering-challenge-37394185

Clutter, sleep and fatigue: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616259/

ADHD and clutter: https://www.additudemag.com/making-peace-with-your-clutter/

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I got thinking about this recently whilst on holiday recently where I was having a lot of lie-ins and

doing a lot of daydreaming.

Coffee: https://www.healthline.com/nutrition/top-evidence-based-health-benefits-of-coffee

Chewing and alertness: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449949/

Chewing and effects on the immune system: https://www.manchester.ac.uk/about/news/research-reveals-surprising-health-benefits-of-chewing-your-food/

Fidgeting and NEAT: https://www.womenshealthmag.com/uk/fitness/fat-loss/a36287384/neat-exercise/

Eating bogies - benefits?: https://pubmed.ncbi.nlm.nih.gov/25344244/

Lie-ins: https://www.theguardian.com/lifeandstyle/2021/sep/13/dream-on-the-surprising-health-benefit-of-a-weekend-lie-in

Missing breakfast: https://www.healthline.com/nutrition/is-skipping-breakfast-bad

Alcohol and cognitive health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866612/

Daydreaming: https://time.com/6256541/why-daydreaming-is-good-for-you/

Bottling up anger: http://news.bbc.co.uk/1/hi/health/8374519.stm

Bouts of anger: https://blog.swedish.org/swedish-blog/new-study-bouts-of-anger-can-take-a-toll-on-your-heart

How to process anger (Dr Gabor Maté): https://www.youtube.com/watch?v=Yh1-y3TzSO4

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Many of us have role models but do they impact our health?

As the Olympics were taking place recently I started to think about

this and in this episode I look at some studies and reveal their

interesting findings.

Role models (an alternative view): https://www.spectator.co.uk/article/the-problem-with-role-models/

Smoking in popular culture: https://truthinitiative.org/research-resources/tobacco-pop-culture/why-smoking-still-being-glamorized-media-and-pop-culture

Study 1: https://www.researchgate.net/publication/380209172_Health_Motivation_in_the_Influencer_Era_Analyzing_Entertainment_Personal_and_Social_Media_Role_Models

Study 2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421350/

Study 2 questionnaire: https://redcap.ctsi.psu.edu/surveys/index.php?s=4L973C8FFL

The importance of mentoring: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2352144/

Chasing your hero: https://www.youtube.com/watch?v=wD2cVhC-63I

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This is a topic close to my heart and is important to address for patients and medical staff.

Race is a sociological construct and differs from ancestry.

It has a surprising impact in medicine, both in terms of care and outcomes for patients. In addition racism

needs stamping out in the medical profession in all corners.

Prostate cancer risk in black men: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826514/

Maternal mortality in black women during and after pregnancy : https://lordslibrary.parliament.uk/maternal-mortality-rates-in-the-black-community/#

South Asians and type 2 Diabetes: https://www.diabetes.org.uk/node/12895

Black people and stroke risk: https://www.healthline.com/health/stroke/why-do-african-americans-have-a-greater-stroke-risk

James Sims: https://www.history.com/news/the-father-of-modern-gynecology-performed-shocking-experiments-on-slaves

Abuse during COVID: https://www.phc.ox.ac.uk/about/staff-stories/racist-abuse-against-asians-during-the-covid-19-pandemic

Head injuries and race in sport: https://apnews.com/article/health-nfl-race-and-ethnicity-sports-066d9fd6bd85f5b5023207467701fde4#

Dr Arora and the GMC: https://www.bmj.com/content/379/bmj.o2619

Beta Thalassemia: https://www.hopkinsmedicine.org/health/conditions-and-diseases/beta-thalassemia

Tay-Sachs Disease: https://www.nhs.uk/conditions/tay-sachs-disease/

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