Episode notes:

1. Introduction: Discussion on the unique variability in how individuals respond to medical cannabis, and the complexities of dosage determination.

2. Dispelling conventional wisdom: Discussing the ineffectiveness of basing cannabis dosage on factors such as age, gender, and kidney or liver function.

3. Case study: Highlighting interpersonal differences in THC dosage requirements between individuals like older women and young men.

4. Unpacking THC: Delving into how THC is processed by the liver into 11-hydroxy THC, its more potent form, and how it impacts individuals differently.

5. Comparative Analysis: Comparing effects of inhaled cannabis and oral THC, highlighting the stronger body effect observed with the latter.

6. Ultra Metabolizers: Discussing the phenomenon of ultra metabolizers who quickly convert THC into inactive metabolites, rendering it less effective.

7. Absorption issues: Discussing the possibility of poor THC absorption due to difficulties in absorbing fats, leading to decreased effectiveness.

8. The endocannabinoid system: Discussing how individual variations in the endocannabinoid system, due to genetics, age, or chronic health issues, can impact a person's response to THC.

9. Influence of food: Discussing how food intake, specifically fat-containing meals, can influence the absorption and effectiveness of oral THC.

10. Alcohol and THC: Discussing the interplay between alcohol and THC, cautioning listeners about the increased effects and potential risks.

11. Practical Advice: Providing practical advice for new cannabis users on how to optimize absorption, such as taking THC with fat-containing food.

12. Conclusion: Emphasizing the need for continued research into the factors influencing individual responses to THC, to improve personalized dosing and patient outcomes.