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Dr. Erica Rosen is perplexed when she sees a young Chinese girl with blue eyes in her San Francisco pediatrics clinic. The girl's mother, Ting, is secretive, and Erica suspects she has entered the country illegally. Later, Erica encounters Ting's son and discovers he has an unusual mutation. Erica learns that Ting's children underwent embryonic stem cell gene editing as part of a secret Chinese government-run program.

Dr. Erica Rosen’s world is turned upside down after a bomber explodes amidst a large crowd entering Oracle Park baseball stadium near her San Francisco home. Many are killed or injured, and police have no leads in solving the case.

Pediatrician Erica Rosen is stymied when two of her patients don't respond to medicine as expected. When other patients later develop strange, unexpected illnesses, she is determined to get to the bottom of it. Meanwhile, the department's newest pediatrician, Dr. Nilsen, appears to be trying to steal her patients. Erica suspects he is after her job as the clinic director. She also discovers Dr. Nilsen has become romantically involved with her trusted assistant, Martha.